Polycarbophil

Experimental Small Molecule

Polycarbophil

Polycarbophil calcium is a synthetic polymer manufactured from the cross-linking of polyacrylic acid with divinyl glycol and a calcium counter-ion. Polycarbophil calcium is a stool stabilizer used to treat constipation. This drug may also be used to help relieve the symptoms of irritable bowel syndrome or diarrhea. Less gas and bloating compared to psyllium laxative products, but can cause heartburn, and belly cramps. It is insoluble in water, dilute acids, and dilute alkali. The material possesses exceptionally high water-binding capacity. is not absorbed, does not interfere with the activity of digestive enzymes or intestinal absorption, possesses satisfactory stability, is physiologically inert, and does not cause gastrointestinal irritation. Polycarbophil calcium is a synthetic polymer manufactured from the cross-linking of polyacrylic acid with divinyl glycol and a calcium counter-ion. Polycarbophil calcium is a stool stabilizer used to treat constipation. This drug may also be used to help relieve the symptoms of irritable bowel syndrome or diarrhea. Less gas and bloating compared to psyllium laxative products, but can cause heartburn, and belly cramps. It is insoluble in water, dilute acids, and dilute alkali. The material possesses exceptionally high water-binding capacity. is not absorbed, does not interfere with the activity of digestive enzymes or intestinal absorption, possesses satisfactory stability, is physiologically inert, and does not cause gastrointestinal irritation.

Summary of Product Characteristics

Field Name Value
NamePolycarbophil
TypeSmall Molecule
GroupsExperimental
DescriptionPolycarbophil calcium is a synthetic polymer manufactured from the cross-linking of polyacrylic acid with divinyl glycol and a calcium counter-ion. Polycarbophil calcium is a stool stabilizer used to treat constipation. This drug may also be used to help relieve the symptoms of irritable bowel syndrome or diarrhea. Less gas and bloating compared to psyllium laxative products, but can cause heartburn, and belly cramps. It is insoluble in water, dilute acids, and dilute alkali. The material possesses exceptionally high water-binding capacity. is not absorbed, does not interfere with the activity of digestive enzymes or intestinal absorption, possesses satisfactory stability, is physiologically inert, and does not cause gastrointestinal irritation.
External IDsWL 140 / WL-140
UNIIW25LM17A4W
CAS number9003-97-8
IndicationPolycarbophil is used to treat constipation and to help maintain regular bowel movements.
PharmacodynamicsRelieves constipation or diarrhea associated with bowel disorders and acute nonspecific diarrhea.
AbsorptionCalcium polycarbophil is not absorbed from the intestine.
Volume of distributionCalcium polycarbophil is not absorbed from the intestine.
Protein bindingCalcium polycarbophil is not absorbed from the intestine.
MetabolismPolycarrbophil calcium is not metabolized and has limited hydrophilic activity in acidic environments.
Route of eliminationExcreted in feces.
Half lifeCalcium polycarbophil is not absorbed from the intestine.
ToxicityThe LD50 of calcium polycarbophil in young adult rats approximated 20 g/kg.
Affected organismsHumans and other mammals