Potassium gluconate

Approved Small Molecule

Potassium gluconate

Potassium gluconate is a salt of Potassium cation and is classified as a food additive by the FDA 7. It is also used as a potassium supplement 10. Potassium gluconate is a salt of Potassium cation and is classified as a food additive by the FDA 7. It is also used as a potassium supplement 10.

This compound belongs to the class of organic compounds known as sugar acids and derivatives. These are compounds containing a saccharide unit which bears a carboxylic acid group.

Structure

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Summary of Product Characteristics

Field Name Value
NamePotassium gluconate
TypeSmall Molecule
GroupsApproved
DescriptionPotassium gluconate is a salt of Potassium cation and is classified as a food additive by the FDA 7. It is also used as a potassium supplement 10.
External IDsE-577 / INS NO.577 / INS-577
IndicationBecause of potassium’s wide-ranging roles in the body, low intakes can increase the risk of illness 8.
PharmacodynamicsPotassium is an essential nutrient. It is the most abundant cation in intracellular fluid, where it plays a key role in maintaining cell function, especially in excitable cells such as skeletal muscles, the heart, and nerves 3. Increases in interstitial potassium play an important role in eliciting rapid vasodilation, allowing for blood flow to increase in exercising muscle 13.
AbsorptionPotassium is rapidly and well absorbed. A 2016 dose-response trial found that humans absorb about 94% of potassium gluconate in supplements, and this absorption rate is similar to that of potassium from potatoes 2.
Volume of distributionDistribution is largely intracellular, but it is the intravascular concentration that is primarily responsible for toxicity 6.
Route of elimination90% of potassium is eliminated via the kidneys. A small amount is eliminated in feces and sweat 6.
ToxicityAcute oral toxicity (LD50): 9100 mg/kg in the mouse MSDS
Affected organismsHumans and other mammals
Taxonomy descriptionThis compound belongs to the class of organic compounds known as sugar acids and derivatives. These are compounds containing a saccharide unit which bears a carboxylic acid group.
KingdomOrganic compounds
Super classOrganic oxygen compounds
ClassOrganooxygen compounds
Sub classCarbohydrates and carbohydrate conjugates
Direct parentSugar acids and derivatives
Molecular frameworkAliphatic acyclic compounds